Quick Summary
Sildenafil can interact with several medications and substances. Some combinations may cause dangerous drops in blood pressure or reduce effectiveness.
- Never combine with nitrates
- Use caution with blood pressure medications
- Alcohol may increase side effects
- Food can delay absorption (not interaction but relevant)
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Major Drug Interactions
Nitrates (Dangerous Combination)
- Nitroglycerin
- Isosorbide mononitrate
- Isosorbide dinitrate
Risk: Severe drop in blood pressure
Alpha-blockers
- Tamsulosin
- Doxazosin
- Terazosin
Risk: Dizziness, hypotension
Other Medication Interactions
- Blood pressure drugs: may amplify hypotension
- HIV protease inhibitors: increase sildenafil levels
- Antifungals (ketoconazole): increase exposure
- Macrolide antibiotics: may increase concentration
Food & Alcohol
High-Fat Meals
Can delay absorption and onset but does not eliminate effectiveness.
Alcohol Consumption
May increase dizziness, hypotension, and reduce erectile performance.
Safety Guidelines
- Avoid combining with nitrates at all costs
- Use caution with cardiovascular disease
- Start with lowest effective dose
- Consult a doctor if on multiple medications
FAQ
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